| abstract |
The present invention relates to a preparation method and application of a single isomer of NUC‑1031, which specifically uses the first step reaction product to separate isomers, and then undergoes two steps of chemical synthesis to prepare a high-purity compound (Sp‑1) combination. The method is easy to operate and low in cost. The final prepared composition contains a single isomer (Sp-1) with high purity, and the HPLC purity is above 97%, and further above 99%. This method is suitable for industrial production, and the prepared combination It can meet the needs of clinical research. Furthermore, the present invention also relates to the use of the composition and a pharmaceutical composition comprising the composition and at least one pharmaceutically acceptable excipient. |