| abstract |
The present invention relates to a method for resolving an atorvastatin "condensate" intermediate, said method comprising the following steps: Step 1, taking the cis-trans isomer mixture of the condensate, heating it with isopropanol as a solvent It dissolves, step 2, filter while hot to remove a small amount of insoluble matter, then add isopropanol to the filtrate, heat to dissolve, step 3, let the solution cool down to room temperature naturally under stirring, there is solid precipitation, collect the solid by filtration, and dry it to obtain the The white solid is (3S,5S)-condensate, step 4, the filtrate filtered in step 3 is concentrated, crystallized under stirring, the precipitate is collected by filtration, and the light yellow solid is (3R,5S)-condensate after drying. |