http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106478558-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f831415b47bf5e1d17667913f934644a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-33 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33 |
| filingDate | 2016-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fd439091b0458547d757a4ba56fbc8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d59103294daa91aa189d5bc19b27cfb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42d2f741590bb8c561ca9ce300c28325 |
| publicationDate | 2017-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106478558-A |
| titleOfInvention | A kind of synthetic method of 4-hydroxymethyl-dihydro-furan-2 (3H)-ketone |
| abstract | The invention belongs to the field of organic synthesis and drug synthesis, in particular to a synthesis method of 4-hydroxymethyl-dihydro-furan-2(3H)-one. This synthetic method is carried out according to the following steps: the first step, 3-oxetanone and ethoxyformyl methylene triphenylphosphine solvent mixed stirring reaction obtains intermediate product 2-(oxetane- 3-base) ethyl acetate; In the second step, the intermediate product 2-(oxetane-3-base) ethyl acetate is successively passed through palladium carbon hydrogenation reduction and hydrolysis under alkaline conditions, and simultaneously completes reduction and oxygen heterocycle Rearrangement to give 4-hydroxymethyl-dihydro-furan-2(3H)-one. The reaction condition of the synthesis method involved in the invention is easy to control, the raw materials are cheap and easy to obtain, the operation and post-treatment process are simple, and it has industrial production value. |
| priorityDate | 2016-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.