| abstract |
The present invention relates to a gemfibrozil oxime derivative and its application as an FXR antagonist, specifically, it provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof and a preparation method thereof, Wherein : R1 is selected from hydrogen, hydroxyl, methyl, methoxy, halogen, nitro; R2 is selected from hydrogen , hydroxyl, methyl, trifluoromethyl, halogen; R3 is selected from hydrogen, hydroxyl, methyl , methoxy, halogen, nitro; R 4 is selected from hydrogen, methyl; R 5 is selected from hydrogen, methyl; R 6 is selected from hydrogen, methyl; X is selected from NH, O, S. In addition, the compound represented by formula (I) or a pharmaceutically acceptable salt thereof has the pharmacological effect of lowering blood lipid, and is a kind of FXR antagonist. |