| abstract |
The present invention relates to the preparation of a class of carboxylic acid derivatives and their application as FXR antagonists, and specifically provides the compound shown in formula (I) or a pharmaceutically acceptable salt thereof and a preparation method thereof, Wherein: R 1 is selected from hydrogen, methyl, methoxy, halogen, nitro, carboxyl; X is selected from NH or O; n1 is 0 or 1; n2 is 0 or 1; R 1 and The group is located at any substitution position on the benzene ring. The compound represented by formula (I) or a pharmaceutically acceptable salt thereof has the pharmacological effect of lowering blood lipid, and is a kind of FXR antagonist. |