http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106474067-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2016-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106474067-B |
| titleOfInvention | Gemcitabine or its salt liposome modified with polyethylene glycol |
| abstract | The invention provides a polyethylene glycol-modified gemcitabine or its salt liposome, comprising gemcitabine or its salt, polyethylene glycol-modified lipids and a phospholipid bilayer, where the phospholipid bilayer material includes phospholipids and cholesterol , gemcitabine or its salt is encapsulated in the phospholipid bilayer, the lipid in the polyethylene glycol modified lipid is interspersed in the phospholipid bilayer, and the polyethylene glycol is exposed outside the phospholipid bilayer; phospholipid, The parts by weight of cholesterol, polyethylene glycol modified lipid and gemcitabine or its salt are 60-120 parts, 10-60 parts, 0.2-6 parts and 2-10 parts respectively. Polyethylene glycol-modified gemcitabine or its salt liposomes provided by the present invention, the liposomes are modified with polyethylene glycol, not only can reduce the occurrence of mutual fusion, aggregation, sedimentation and other phenomena between liposomes, It can also effectively reduce the speed and degree of ingestion by monocytes and macrophages, and prolong the systemic circulation time. The invention also provides the preparation method and application of the liposome. |
| priorityDate | 2016-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 202.