abstract |
The present invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of an adenovirus hexon protein, a pharmaceutical composition comprising the recombinant adenovirus and its medicinal use. In particular, the present invention relates to an oncolytic adenovirus having a sequence encoding an albumin binding moiety inserted in the hypervariable region 1 (HVR1) of the hexon protein coding sequence, and its use in the prevention and/or treatment of cancer. |