| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e2ba784a11bf94f0d7af0b295a8c05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-56 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 |
| filingDate |
2015-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8edea921c3678bccc01b82900e870c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ae6445a63ac82f20de953757c925e08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b7330558e4fdd977f438c712c0b6742
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b224c0b826151d2676b9de650776f2c0 |
| publicationDate |
2017-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106467465-A |
| titleOfInvention |
A kind of high-purity latanoprost and its preparation method and application |
| abstract |
The invention discloses a high-purity latanoprost as well as its preparation method and application. In the high-purity latanoprost of the present invention, the impurity whose structure is represented by formula II is not higher than 0.1%. The preparation method comprises steps: (1) subjecting the compound of formula IV (latanoprost intermediate 1) to the compound of formula V (latanoprost intermediate 2) through wittig reaction; After washing and purifying, after dehydroxylation protection or non-deprotection, react with iodoisopropane to obtain the crude drug substance of latanoprost; and (3) load the crude drug substance of latanoprost to a silica gel column, Elution, chromatographic purification to obtain the high-purity latanoprost. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115991691-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115991691-B |
| priorityDate |
2015-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |