http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106466296-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 |
| filingDate | 2016-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106466296-B |
| titleOfInvention | A kind of camptothecine it is nanocrystalline and preparation method thereof |
| abstract | The present invention provides nanocrystalline compositions of insoluble anti-tumor medicament camptothecin analogues and preparation method thereof.Using the alkali soluble acid of optimization it is heavy-high pressure homogenization: gradient speed acid adding after medicinal powder alkali soluble settles out nanocrystalline；Acid is heavy in two times and removes generated salt by centrifugation step；High pressure homogenization further decreases partial size.Gained camptothecin is nanocrystalline preferably with the average grain diameter of 100-150m; it is evenly distributed; only need to be added minute quantity PLURONICS F87 be freeze drying protectant can freeze-dried powder form long-term preservation, the shaking of 5% glucose solution, which is added, in when use can directly restore the state before freeze-drying.Method is easy, reproducible, is suitble to large-scale production.There is good slow release effect outside gained nanocrystal；More commercially available injection can improve the circulation time in blood plasma, improve drug organize in vivo in distribution, and have stronger antitumous effect, with wide development prospect. |
| priorityDate | 2016-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.