| abstract |
The present disclosure relates to isolated anti-FcRn antibodies or fragments thereof, methods for their preparation, compositions for treating autoimmune diseases comprising the antibodies, and methods for treating and diagnosing autoimmune diseases using the antibodies, wherein the antibodies are combined with FcRn ( Represents antibodies that bind to neonatal Fc receptors, also known as FcRP, FcRB or Brambell receptors), which are receptors with high affinity for IgG. The FcRn-specific antibodies of the present disclosure bind FcRn non-competitively with IgG to reduce serum pathogenic autoantibody levels, and thus can be used to treat autoimmune diseases. |