| abstract |
The present invention relates to compounds of formula (I), wherein ... C ... is -CH 2 - or -CH 2 -CH 2 -; X is -NH-, -C(O)NH- or -NHC (O)NH-; Ar is phenyl or a 5- or 6-membered heteroaryl group containing one or two N atoms; R is halogen, lower alkyl, halogen-substituted lower alkyl, lower alkoxy, cycloalkane - lower alkoxy substituted by radical, lower alkoxy substituted by halogen or cycloalkyl; -()- is -CH 2 -; n is 0 or 1; m is 0, 1 or 2; Acid addition salts, with respect to all racemic mixtures, with respect to all their corresponding enantiomers and/or optical isomers, said compounds being useful in the treatment of depression, anxiety, bipolar disorder, attention deficit ADHD, stress-related disorders, psychotic disorders, schizophrenia, neuropathy, Parkinson's disease, neurodegenerative disease, Alzheimer's disease, epilepsy, migraine, hypertension, psychoactive substance abuse, Metabolic diseases, eating disorders, diabetes mellitus, diabetic complications, obesity, dyslipidemia, energy expenditure and assimilation disorders, temperature homeostasis disturbances and dysfunctions, sleep and circadian rhythm disturbances, and cardiovascular disease. |