| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_331524805723a5a4cada42ce5fc156e3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
| filingDate |
2015-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9993f9e500ddb36df6326b735386ff89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3144a71adf89c7e32330cdaeea5ced4b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef165f4456bbf7e7053bc05952cb24aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_179c2776f3fe9e136ed12595d204b028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_199912dd2a5668a928a2ae68fe31b60f |
| publicationDate |
2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106459035-A |
| titleOfInvention |
N2-phenyl-pyrido[3,4-D]pyrimidine-2,8-diamine derivatives and their use as MPS1 inhibitors |
| abstract |
The present invention relates to compounds of formula (I), wherein R 1 , R 2 , R 3 and R 4 are all as defined herein. It is known that the compounds of the present invention inhibit the spindle checkpoint function of Mps1 kinase directly or indirectly by interacting with the single spindle 1 (Mps1 - also known as TTK) kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases such as cancer. The invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising these compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113574057-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110753542-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110799183-A |
| priorityDate |
2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |