| abstract |
Disclosed herein are methods for the preparation of 2-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidine-1 -yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile free base (compound ( I)), the salts of compounds (I) and the process of solid state forms of said salts. Also disclosed herein are pharmaceutical compositions comprising such salts and solid state forms thereof, as well as methods of using Compound (I) or a pharmaceutically acceptable salt thereof for the treatment of cancer, autoimmune diseases and inflammatory diseases. |