| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-5428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-5434 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6888 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-125 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate |
2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2020-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106434728-B |
| titleOfInvention |
Recombinant bacillus subtilis for expressing highly pathogenic avian influenza H5N1 hemagglutinin HA protein |
| abstract |
The invention relates to a recombinant bacillus subtilis (B.S. -HA) for expressing highly pathogenic Avian Influenza (AIV) H5N1 hemagglutinin HA protein, belonging to the field of biotechnology and genetic engineering. The invention successfully constructs a highly pathogenic avian influenza hemagglutinin HA protein recombinant bacillus subtilis expression plasmid pHT43, and successfully transfers the recombinant bacillus subtilis expression plasmid into a bacillus subtilis WB800N strain (B.S) by electric shock. Western-blot verifies that the highly pathogenic avian influenza hemagglutinin HA protein can be successfully expressed in the recombinant bacillus subtilis. Oral immunization stimulates the body of a 10-day-old chick to produce an effective level of AIV-specific immune response. The recombinant bacillus subtilis (B.S. -HA) is expected to be developed into a genetic engineering oral vaccine for preventing highly pathogenic avian influenza. |
| priorityDate |
2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |