http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106432230-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106432230-B |
| titleOfInvention | A kind of application in terms of pyrido pyrazolones and its anti-influenza A virus |
| abstract | The invention provides a kind of pyrido pyrazolones and its application in influenza A virus medicament is prepared.The invention demonstrates that a kind of pyrido pyrazolones, are named as compound J1, find that the compound has the activity of significant broad spectrum influenza virus through a series of researchs.The experiment of H5N1 and H7N9 hypotypes pseudovirus is carried out from the compound J1 of non-toxic concentrations, as a result shows that the compound has the significant activity for suppressing influenza A virus and entering and is in dose dependent.Study on mechanism shows compound J1 targeting influenza virus hemagglutinin HA 2 subunits, suppresses influenza virus and carries out film fusion, so as to suppress the entrance of influenza virus, can be used for the medicine for preparing prevention and treatment influenza.Therefore, compound of the invention can be used for the prevention or treatment of influenza A virus, and the drug candidate for being expected to turn into preventing and treating influenza is furtherd investigate and developed. |
| priorityDate | 2016-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 332.