http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106432201-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate | 2016-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106432201-B |
| titleOfInvention | A kind of preparation method of candesartan cilexetil crystal |
| abstract | The invention belongs to the technical field of crystallization, and particularly relates to a crystallization preparation method of candesartan medoxomil. The technical scheme of the present invention is as follows: in the first step, candesartan cilexetil is added to the alcohol aqueous solution, the solid-liquid ratio of the solution is 0.01g/g～0.1g/g, and the solution is continuously stirred and dissolved for 30～60 minutes at 25～45°C The second step filtration, the filtrate is moved into the crystallizer and kept at 25～45 ℃, and the water of 1～3 times of the water in the initial solution is added to the crystallizer, and the flow rate is 0.5～2g/min; Add seeds to the crystallizer, and grow the crystals for 1 to 2 hours; then add water 10 to 20 times the amount of water in the initial solution into the crystallizer, with a flow rate of 0.5 to 5 g/min, and grow the crystals for 2 to 4 hours; the third step filter. The invention provides a preparation method of candesartan medoxomil crystal form I with controllable particle size. |
| priorityDate | 2016-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.