http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106432136-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2016-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106432136-B |
| titleOfInvention | A kind of Hydrochioro and atenolol are total to unformed system and preparation method thereof |
| abstract | The invention discloses a kind of Hydrochioros and atenolol to be total to unformed system and preparation method thereof, there is not sharp diffraction maximum from the point of view of powder x-ray diffraction spectral results in the amorphous system, differential scanning calorimeter finds single glass transition temperature, infrared spectrometer finds the broadening of absorption peak and the variation of peak shift, can determine from above result and form a kind of unformed system altogether with very strong intermolecular interaction.And the experiment for carrying out solubility and intrinsic dissolution rate unformed altogether to obtaining, compared with crystalline pharmaceutical, solubility and dissolution rate are significantly improved.Also the physical stability of unformed system altogether is characterized simultaneously, the results showed that the system can stablize preservation 30 days under 4 DEG C and 25 DEG C of drying conditions.The invention further relates to two kinds of total unformed preparation methods, unformed system provides two kinds of approach altogether for preparation for freeze grinding method and solvent evaporated method. |
| priorityDate | 2016-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.