http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106432122-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-22 |
| filingDate | 2016-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106432122-B |
| titleOfInvention | A kind of preparation method of meropenem intermediate chlorine propionyl spiral shell benzoxazine hexamethylene |
| abstract | The present invention provides a kind of preparation methods of meropenem intermediate chlorine propionyl spiral shell benzoxazine hexamethylene, use the lower α-chlorpromazine chloride of reactivity, cooperate specific raw material one to work, not but not reduces reaction yield, instead reaction yield is greatly improved；Simultaneously, since α-chlorpromazine chloride activity is lower, so that the side reaction for participating in reaction is less, the impurity in products obtained from is less, to which yield and the higher chlorine propionyl spiral shell benzoxazine hexamethylene of purity be made, and this yield and the higher chlorine propionyl spiral shell benzoxazine hexamethylene of purity can replace Spirobromin benzoxazine hexamethylene to prepare Meropenem.In addition, without magnetic solid base catalyst, reaction condition is safer in the synthesis technology of chlorine propionyl spiral shell benzoxazine hexamethylene provided by the invention, reaction route is simple, convenient post-treatment, and raw material and catalyst are cheap and easy to get, safety and environmental protection, preparation cost is lower, is more suitable for industrialized production. |
| priorityDate | 2016-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.