| abstract |
The invention discloses amido sulfur alcohol compound and preparation method thereof and its application in radiation protection, the compound has the structure of Formulas I: Wherein, A 1 It is selected from :-C (O) NR 8 ‑、‑S(O) 2 ‑NR 8 ‑、‑S(O)NR 8 ‑、‑R 7 ‑NR 8 , A 2 It is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C 1‑6 Alkyl, R 1 、R 2 、R 5 、R 6 It may be the same or different, be selected from: hydrogen, substituted or unsubstituted C 1 ‑C 5 Alkyl or miscellaneous alkyl, n are the integer of 0-20000, R 3 、R 4 Independently selected from: hydrogen, X, substituted or unsubstituted C 1‑6 Alkyl, X are selected from: F, Cl, Br, I, R 7 It is selected from: substituted or unsubstituted C 1 ‑C 6 Alkyl, R 8 It is selected from: hydrogen, substituted or unsubstituted C 1 ‑C 6 Alkyl.The compound has the function of biological damage caused by reducing ionising radiation, while also having the function of extending the animal survival phase radiated and survival rate. |