http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106431980-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c2ac95be79891536978d04dc7195ee4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-14 |
| filingDate | 2016-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a806b79f0b7db8076e01eec9684a9d5 |
| publicationDate | 2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106431980-A |
| titleOfInvention | Synthesis method of pyrimethamine drug intermediate p-chlorobenzonitrile |
| abstract | A synthesis method of a pyrimethamine drug intermediate p-chlorobenzonitrile includes the following steps that1.3 mol of p-chlorobenzyl chloride and 0.56 mol of stannous chloride are added to a reaction container provided with a mixer, a thermometer, a reflux condenser and a dropping funnel, the stirring speed is controlled to be 130-160 rpm, the solution temperature rises to 90-95 DEG C, 1.5-1.7 mol of cyanamide is slowly added, the dropwise adding time is controlled to be 1-2 hours, stirring reaction continues for 4-5 hours, the solution temperature is reduced to 10-15 DEG C, 230 ml of sodium chloride solution is added, a water layer is removed, an oil layer is washed with a salt solution, acetonitrile washing is performed, reduced pressure distillation is performed, a fraction recrystallizes in ethyl acetate to obtain the crystal p-chlorobenzonitrile, wherein the mass fraction of the sodium chloride solution in the step is 15-20%, and the salt solution in the step is any one of potassium bromide and sodium nitrate. |
| priorityDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.