http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106431907-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17fa04088f285d891117ee10818886c0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 |
| filingDate | 2016-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a971fbff6a9200d2795c7f80755d0ccc |
| publicationDate | 2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106431907-A |
| titleOfInvention | Synthesis method of carbenicillin drug intermediate phenylmalonic acid monophenyl ester |
| abstract | The invention provides a synthesis method of carbenicillin drug intermediate phenylmalonic acid monophenyl ester. The synthesis method includes the following steps that 1, 0.17-0.19 mol of phenylmalonic acid and 100 ml of toluene solution are added into a reaction container provided with a stirrer and a thermometer, 0.18 mol of N-(3-hydroxyphenyl)acetamide is slowly added, the solution temperature is controlled to range from 90 DEG C to 85 DEG C, the reaction time is controlled to range from 4 h to 5 h, reduced pressure distillation is carried out, toluene is distilled out, 100 ml of ethylenediamine solution and 0.16-0.17 mol of phenol are added into leftovers, heating reflux is carried out for 3-3.5 h, the solution temperature is reduced to 40-45 DEG C, washing is carried out with 50 ml of saline solution, extraction is carried out with a potassium hydroxide solution, the pH of the solution is controlled to range from 8 to 9, extracting solutions are mixed, washing is carried out with 200 ml of toluene solution, a water layer is washed with a potassium bicarbonate solution, generated grease is fully extracted with a methylamine solution, methylamine layer washing and dehydrant dehydrating are carried out, a solvent is distilled out, generated solids are recrystallized with isopropanol, and colorless needle crystals phenylmalonic acid monophenyl ester are obtained. |
| priorityDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.