| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6ed83b9d5c28c6c356d1d08d58501e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc8b706fb22ca0baba35f66ce3e501ef |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate |
2015-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_342c64b0fd9278d3b467b2ea061cb7bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91d1ad72906ec6927ab0347caa0209a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8de1eb5e8334af6fbea13833e76e2513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83344aa23de864eb82d0b6d0244368f4 |
| publicationDate |
2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106431898-A |
| titleOfInvention |
Synthesis and use of phenylpropionic acid derivatives |
| abstract |
The invention discloses a series of phenylpropionic acid derivatives, a preparation method thereof, and a use of the derivatives in pharmacy. The derivatives are compounds represented by formula I. Pharmacodynamic experiments show that the compounds of formula I have good agonist activity to GPR120; an in-vivo metabolism research result shows that the compounds of the formula I have good metabolism stability; and unexpectedly, the compounds have substantially higher agonist activity to the GPR120 after a difluoro substitute group is introduced to a phenyl ring at the carboxyl terminal of the compounds of the formula I. The compounds of the formula I can be used for drugs for preventing diabetes, obesity and other metabolic diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112876352-A |
| priorityDate |
2015-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |