http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106421803-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 |
| filingDate | 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106421803-B |
| titleOfInvention | A composite intelligent nano-drug delivery system for the treatment of EML4-ALK fusion mutant non-small cell lung cancer and its preparation method |
| abstract | The present invention provides a composite intelligent nano drug-carrying system for the treatment of EML4-ALK fusion mutant non-small cell lung cancer and a preparation method thereof. According to the needs of the treatment of EML4-ALK fusion mutant non-small cell lung cancer, this method selects two targets, ALK and micRNA-301, for gene therapy, and induces apoptosis by promoting the expression of tumor suppressor gene BIM in EML4-ALK type lung cancer. The invention uses gold nanoshells as the core, uses chemical bonds to connect the interference sequences of ALK and micRNA-301 on its surface, and uploads doxorubicin to the outermost layer through electrostatic adsorption. This structure not only improves the stability of nucleic acid drugs, but also can accumulate at the tumor site, realizing the integration of hyperthermia, chemotherapy and gene therapy, and providing a new treatment for EML4-ALK fusion mutant non-small cell lung cancer. methods and ideas. |
| priorityDate | 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.