http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106414476-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 |
| filingDate | 2014-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106414476-B |
| titleOfInvention | Methods for purifying immunoglobulins |
| abstract | The present invention relates to a method for purifying immunoglobulin, more particularly, the method for purifying immunoglobulin comprises: solubilizing plasma protein fraction I+II+III or fraction II+III containing immunoglobulin; Caprylate is added to the solution to cause precipitation; dialysis and concentration are performed after removing the precipitate; anion exchange resin and ceramic cation exchange resin purification processes are performed to effectively remove the added solvent for virus inactivation and decontamination and performing the elution while maintaining a constant level of salt concentration to keep the polymer content of the immunoglobulin low. According to the method for preparing intravenous immunoglobulin of the present invention, the precipitation step of preparing the component II from the component I+II+III or the component II+III as a raw material can be omitted, and by using the first sodium caprylate precipitation, Anion-exchange chromatography and cation-exchange chromatography solve the problems involving complicated steps and low yields that occur in conventional preparation methods utilizing polyethylene glycol treatment processes. Furthermore, when the method for purifying immunoglobulins according to the present invention is used, the efficiency of removing impurities and thrombotic substances can be improved, and the polymer content of immunoglobulins can be maintained, thereby producing stable immunoglobulins of improved quality. |
| priorityDate | 2014-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.