http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106397514-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-067 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 |
| filingDate | 2016-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106397514-B |
| titleOfInvention | A kind of double labelling uridine-(13C,15N2) synthetic method |
| abstract | The present invention relates to a kind of double labelling uridine-( 13 C, 15 N 2 ) synthetic method, this method using anhydrous benzene as solvent, double labelling urea-( 13 C, 15 N 2 ) and propiolic acid be raw material carry out cyclization, obtain double labelling uracil-( 13 C, 15 N 2 )；In Ar 2 Under atmosphere, acetonitrile as solvents, double labelling uracil-( 13 C, 15 N 2 ) and 1- acetoxyl group -2,3,5- thribenzoyl-β-D-RIBOSE mixing, are subsequently added into hexamethyldisilazane and trifluoromethane sulfonic acid trimethyl silicone grease, the intermediate obtained after post-treated is hydrolyzed with ammonium hydroxide, can be obtained double labelling uridine-( 13 C, 15 N 2 ).Compared with prior art, present invention process is simple, and yield is higher, and isotope abundance does not decline, be suitble to Laboratory Production double labelling uridine-( 13 C, 15 N 2 )。 |
| priorityDate | 2016-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.