http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106397408-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 |
| filingDate | 2015-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106397408-B |
| titleOfInvention | 5- methyl -2 (1H) Pyridione derivatives and its preparation method and application |
| abstract | The invention discloses (1H) Pyridione derivatives of 5- methyl -2 shown in formula I or its crystal form, pharmaceutically acceptable salt, hydrate, solvate or pro-drugs: where X is selected from S or NH；R 1 ~R 4 Separately or concurrently it is selected from hydrogen, halogen, C 1 ~C 6 Alkyl, C 1 ~C 6 Alkoxy.The present invention provides a kind of new 5- methyl -2 (1H) Pyridione derivatives, apparent inhibiting effect is all had to fibroblast proliferation and fibroblasts to secrete fibronectin (Fn), can be used for preparing the drugs such as treatment or prevention fibrotic disease, tumour；The preparation method of compound shown in formula I has many advantages, such as that process is few, step is easy, reaction condition is mild, low energy consumption, high-efficient, at low cost, environmentally protective, the application being very suitable in industry. Formula I. |
| priorityDate | 2015-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.