http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106397159-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17fa04088f285d891117ee10818886c0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-46 |
| filingDate | 2016-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9396db198628b4c20cec9bb4939183de |
| publicationDate | 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106397159-A |
| titleOfInvention | Synthetic method of aurone anticancer compound drug intermediate 2,4,6-trihydroxyacetophenone hydrate |
| abstract | The invention relates to a synthetic method of aurone anticancer compound drug intermediate 2,4,6-trihydroxyacetophenone hydrate. The synthetic method comprises the following step of (i) adding 0.21 mol of phloroglucinol, 0.41 mol of 4-chlorophenethylamine, 200 ml of butyl acetate, and 0.02 to 0.025 mol of cuprous bromide in a reaction container provided with a stirrer, a thermometer and a reflux condenser, reducing the solution temperature to be 3 to 5 DEG C, controlling the stirring speed to be 100 to 120rpm, standing for 30 to 35h, filtering to obtain orange-yellow solid imine bromate, washing through butanol, placing the solid into the 3L reaction container, adding 1.5 to 1.7L of water, rising the solution temperature to be 80 to 85 DEG C, refluxing for 3 to 3.5h, decoloring through a molecular sieve, suction filtrating, washing a filter cake through a paraxylene solution, combining filter liquor and a scrubbing solution, reducing the solution temperature to be 5 to -9 DEG C, placing for 30 to 35h, filtering a precipitated colorless solid, drying at low temperature, and obtaining the 2,4,6-trihydroxyacetophenone hydrate. The mass fraction of the butyl acetate in the step (i) is 40 to 55 percent. |
| priorityDate | 2015-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.