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filingDate 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106390195-B
titleOfInvention A kind of method of modifying of collagem membrane
abstract The invention discloses a kind of method of modifying of collagem membrane: using culture plate as template, collagen, freeze overnight is added;For 24 hours by gained sample vacuum freeze drying, collagem membrane is prepared;Epigallo-catechin gallate (EGCG) is subjected to solution preparation;The collagem membrane of preparation is placed in precrosslink in EGCG, is soaked in the 0.05mol/L acetum containing EGCG, for 24 hours in 4 DEG C of crosslinkings, lXPBS buffer rinses 3 times;The composite membrane prepared is immersed in 1% PEG20000, soaked overnight, then flushed three times with PBS buffer solution, lyophilized overnight.The beneficial effects of the present invention are: provide a kind of collagen composite membrane for possessing more preferable mechanical performance, anti-inflammatory and biocompatibility, improve the mechanical performance of former collagem membrane, reduce drug-collagen composite membrane bio-toxicity, it has a good application prospect, provides new selection for the operation of the related bones increment such as guided bone regeneration.
priorityDate 2016-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 34.