http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106380414-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-58 |
| filingDate | 2016-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106380414-B |
| titleOfInvention | A kind of mefenamic acid and its synthesis technology |
| abstract | The invention discloses a kind of mefenamic acid, which is with 0-chloro-benzoic acid and 2, and 3 dimethylanilines are reactant, under conditions of copper catalyst and alkalescent salt make acid binding agent, carries out C N condensation reactions and obtains.The present invention also provides a kind of synthesis technology of mefenamic acid, including：2,3 dimethylanilines, strong-acid cation-exchange resin, 0-chloro-benzoic acid, sodium bicarbonate, copper catalyst, sodium acetate and ethyl phenenyl azochlorosulfonate acid sodium are separately added into condensation reaction tank, synthesizes the first reaction solution；0-chloro-benzoic acid, sodium bicarbonate and copper catalyst are sequentially added into the first reaction solution, liquid caustic soda is then added dropwise, synthesizes the second reaction solution；The pH value for adjusting second reaction solution obtains condensation liquid；Decoloration is filtered to condensation liquid and purification processes obtain mefenamic acid.The synthesis technology of mefenamic acid provided by the invention has that by-product is few, high income, safety, environmental protection, energy efficiency, it is easy to operate the advantages of. |
| priorityDate | 2016-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.