http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106365978-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-15 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-02 |
| filingDate | 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106365978-B |
| titleOfInvention | A kind of preparation method of the fluoro- 6- methoxy benzoic acid of 2,3- bis- |
| abstract | The present invention provides the preparation methods of the fluoro- 6- methoxy benzoic acid of 2,3- of one kind bis-, comprising: (1) prepares the tetrahydrofuran solution of lithium diisopropyl amido；(2) -75~-65 DEG C are cooled to, the tetrahydrofuran solution of 3,4- difluoroanisole is added dropwise into the tetrahydrofuran solution of lithium diisopropyl amido, rear 50~70min of insulation reaction is added dropwise；(3) CO is passed through into reaction solution 2 Gas maintains the temperature at -75~-70 DEG C, is stirred to react 20~40min；(4) dilute hydrochloric acid is added dropwise into reaction solution, maintains the temperature at 0~10 DEG C, adjusts pH to 1~2, is stirred to react 20~40min and obtains crude product；(5) crude product is post-treated obtains the fluoro- 6- methoxy benzoic acid of target product 2,3- bis-.The present invention is raw material using 3,4- difluoroanisole, and raw material is simple and easy to get, with the organic base lithium diisopropyl amido of non-nucleophilic, the fluoro- 6- methoxy benzoic acid of 2,3- bis- is prepared, simplifies production technology, reduce production cost, 2,3- bis- fluoro- 6- methoxy benzoic acid high incomes. |
| priorityDate | 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.