| abstract |
The invention discloses a 3,4-diphenyl-4H-1,2,4-triazole derivative, a preparation method and an application thereof. Specifically, the present invention relates to 3,4-diphenyl-4H-1,2,4-triazole derivatives having a structure of formula (I), stereoisomers thereof or pharmaceutically acceptable salts thereof, wherein the formula ( The definition of each substituent in I) is the same as the definition in the description. These compounds with novel structures have heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, and have broad application prospects. |