| abstract |
The invention relates to a synthesis method of a nucleoside compound, in particular to a preparation method of a compound shown as formula I and a compound shown as formula II in the specification. In the formula I and formula II, R1 and R2 are respectively a hydroxyl protecting group independently, preferably benzoyl, triphenylmethyl, disubstituted phenyl, acetyl or tert-butyldimethylsilyl; R3 and R4 are alkyl (preferably alkyl of C1-C10, more preferably methyl and ethyl) or halogen (like F, Cl or Br); and B is any of the following groups shown as the specification, wherein R5 is hydrogen or alkyl (preferably alkyl of C1-C10, more preferably methyl); X is hydroxyl or amino; and Y is sulfur or selenium. |