| abstract |
The present invention relates to the synthesis of substituted heterocyclic compounds and pharmaceutical combinations containing these compounds: all capable of inhibiting or antagonizing a receptor family of tyrosine kinases, tropomyosin-related kinase (Trk), in particular neuronal Receptor for growth factor (NGF)-TrkA. The invention also relates to the use of these compounds in the treatment and/or prevention of pain, cancer, vascular restenosis, atherosclerosis, psoriasis, thrombosis, disorders associated with dysmyelination or demyelination A disease, disorder or injury, or a disease or disorder associated with abnormal activity of nerve growth factor TrkA. |