abstract |
The present invention provide as following formula I Benzisoelenazolone quinoline and or its pharmaceutically acceptable salt, hydrate, solvate, crystalline forms or diastereomer, and above-claimed cpd or compositions treating, improving and/or prevent the application in Alzheimer disease drugs.Experiment shows, the Benzisoelenazolone quinoline in the present invention has the simulation activity of glutathione peroxidase of excellence, suppression A beta peptide aggregation effect and metal ion chelating capacity, for Mutiple Targets anti-Alzheimer disease bioactive molecule.Above-mentioned Benzisoelenazolone quinoline shown in formula I, the wherein R in Formulas I 1 、R 2 、R 3 、R 4 , X is defined as in the description. |