| abstract |
The invention discloses aryl alkyl asymmetry over cure class compound and its synthetic method shown in a kind of formula (3), with formula (1) aryl boric acid and formula (2) R 2 SSCOR 3 For reaction raw materials, under metallic copper catalyst action, reaction obtains the aryl alkyl asymmetry over cure class compound.Reaction condition of the present invention is gentle, and raw material is cheap and easy to get, operation is simple, yield is higher, in reaction using cheap metal as catalyst, it is economical and practical, it is environmentally friendly；Reaction substrate is easily prepared；Reaction efficiency is high after reaction amplification.The compound that aryl alkyl asymmetry over cure class compound shown in formula (3) prepared by the present invention can be used in the further potential drug containing C S keys such as synthesis benzyl (phenyl) thioether, benzyl (4 methoxyphenyl) thioether.The present invention has wide application prospect and practical value. |