http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106278964-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fe6d6d112362971ecd356a559b1d6bf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 |
| filingDate | 2016-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4596d6167243234d302d3c6fdd674d9 |
| publicationDate | 2017-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106278964-A |
| titleOfInvention | The preparation method of Florfenicol |
| abstract | The invention relates to a preparation method of florfenicol, which belongs to the technical field of drug synthesis. The preparation method of florfenicol of the present invention is prepared by taking D-p-thymphenylphenylserine ethyl ester as raw material through reduction reaction, ring closure reaction, fluorination reaction and hydrolysis reaction. The fluorination reaction uses dichloromethane solvent, cyclization product and fluorination reagent as reaction raw materials, wherein the mass ratio of the cyclization product to fluorination reagent is 1.25-1.30:1. The preparation method of the present invention has the advantages of simple process operation and low cost, and the by-products of the fluorination reaction are reduced through the control of reaction conditions and the use of additives, so that the method of the present invention can obtain high-purity , Florfenicol products with less impurities are beneficial to control product costs and improve production efficiency. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109456238-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113402475-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116496190-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109776364-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108329240-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019091179-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108329240-B |
| priorityDate | 2016-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.