http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106278928-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2d347cf83d7791aa91ff4990cec87d2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8df0ad286f6aba92800b9571e0a5d34a |
| publicationDate | 2017-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106278928-A |
| titleOfInvention | A kind of synthetic method of oseltamivir phosphate isomer impurity |
| abstract | The invention belongs to the field of medicine and chemical industry, and specifically relates to a method for synthesizing oseltamivir phosphate isomer impurity (formula I). The main steps are: use the starting material of compound II to react with compound III under the catalysis of a chiral Lewis acid catalyst, filter off the catalyst and evaporate the solvent to dryness, then form a salt with an organic acid in a suitable solvent for purification, and decompose After separation, the compound IV was obtained, and then the amino protecting group was removed by hydrogenolysis to form a phosphate, and the target compound was obtained by purification. The identification, preparation and purification of the impurity provide a more effective means for the quality control of oseltamivir phosphate bulk drug. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109890790-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018233562-A1 |
| priorityDate | 2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.