http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106278776-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4461d7f4199f282dc81529d76def990 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C11-22 |
| filingDate | 2016-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b51d2681b6e853dcd1198bf077700e2 |
| publicationDate | 2017-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106278776-A |
| titleOfInvention | A kind of synthetic method of terbinafine pharmaceutical intermediate tert-butyl acetylene |
| abstract | nullA kind of synthetic method of terbinafine pharmaceutical intermediate tert-butyl acetylene，Comprise the steps: agitator is being installed、Thermometer、Dropping funnel、In the reaction vessel of condenser，Add bisulfite potassium solution 310ml,Hexane 300ml,Raise solution temperature to 90 95 DEG C，Control mixing speed at 150 170rpm,Dropping 1，1 diaminourea 3,3 dimethylbutane 0.73mol,Time for adding controls at 3 5h,Add hypochlorous acid phenyl ester 0.81 0.84mol,React 90 120min,Raise solution temperature to 110 115 DEG C，Continue reaction 3 5h,Reduce solution temperature to 10 15 DEG C，Separate out solid，Filter，Brine，Acetonitrile washs，Decompression distillation，Collect the fraction of 100 108 DEG C，Recrystallization in hexamethylene，Obtain crystals tert-butyl acetylene. |
| priorityDate | 2015-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.