| abstract |
The invention discloses a kind of high-glycosylation human growth hormone's fusion protein.Fusion protein described in human growth hormone's fusion protein of the present invention contains human growth hormone (hGH), flexible peptide linker (L), human chorion gonadotrophic hormone beta subunit carboxyl terminal rigidity peptide (CTP) and human normal immunoglobulin's Fc fragment successively from N end to C end.The invention also discloses a kind of efficient method preparing this kind of fusion protein.The fusion protein that the present invention builds has more excellent internal drug effect than restructuring hGH, the circulating half-life in vivo of prolongation, and administration frequency is substantially reduced and bioavailability improves；Its production process is simpler, efficiently simultaneously. |