| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21109
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-1006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-0065 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0602
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21109
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-66 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 |
| filingDate |
2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0552ead2a61dae0209c1a136183bc5c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9693847a62a8b0985d065c97d4a00bef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_896d8ee5250016e95289bdeac49ce5c2 |
| publicationDate |
2016-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-106255749-A |
| titleOfInvention |
Novel Vertebrate Cells and Methods for Recombinant Expression of Polypeptides of Interest |
| abstract |
The present application relates to isolated vertebrate cells and the like suitable for recombinant expression of a polypeptide of interest, wherein the vertebrate cell is altered to impair the function of an endogenous protease interstitial protease and wherein the cell comprises at least one heterologous protein encoding a polypeptide of interest Polynucleotides, wherein the polypeptide of interest is secreted by a cell. It was found that production of a recombinant polypeptide of interest using corresponding vertebrate cells significantly reduces cleavage of the polypeptide of interest secreted into the cell culture medium. Improved production and screening methods are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111107870-A |
| priorityDate |
2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |