| abstract |
The invention discloses a kind of nicotinic acid or .gamma.-pyridinecarboxylic acid compounds and application thereof.The compound that the present invention provides, for compound shown in Formulas I or its pharmaceutically acceptable salt, ester, solvate.The test of pesticide effectiveness proves, the mercaptonicotinic acid compounds that the present invention provides can suppress botulinum toxin endopeptidase activity in vitro, botulinum toxin intoxication mice is had significant protective effect simultaneously.Based on this, the compound that the present invention provides can be used for preparation prevention and/or treatment botulinum toxin exposes and/or the medicine of poisoning. |