http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106222183-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2016-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106222183-B |
| titleOfInvention | Target siRNA and its application of people IRAK1 gene |
| abstract | The present invention relates to field of biotechnology, the sequences of small interfering RNAs and its application, the siRNA of the targeting people IRAK1 gene of specifically a kind for the treatment of dental caries include positive-sense strand and antisense strand, and the nucleotide sequence of the positive-sense strand is as shown in SEQ ID NO:2；The nucleotide sequence of the antisense strand is as shown in SEQID NO:3.The sequences of small interfering RNAs that the present invention obtains is not found in previous disclosed report, it can be interfered after the transcription of IRAK1 gene, to which specificity reduces the protein expression of IRAK1, the expression of NF- κ B in inflamed human dental pulp stem cell can be reduced, reduce the generation of dental pulp stem cell inflammatory factor-tumor necrosis factor, the development for inhibiting inflammation, promotes breaking up at dentine for dental pulp stem cell, new therapeutic scheme is provided for dental caries. |
| priorityDate | 2016-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.