http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106222155-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-90 |
| filingDate | 2016-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106222155-B |
| titleOfInvention | Polypeptide and application thereof in preparation of colitis and colitis-related colorectal cancer drugs |
| abstract | The invention relates to the technical field of biology, in particular to a small molecular polypeptide which has an amino acid sequence shown in SEQ ID NO. 1. The invention also provides application of the small molecule polypeptide in preparing a medicine for treating colitis or colorectal cancer related to colitis. By the treatment of the small molecular polypeptide, the colon length, the tumor number and the like of a mouse in a treatment group are obviously lower than those of a control group; the intestinal tissue proliferation index of the colorectal cancer mouse related to the colitis is obviously reduced; meanwhile, the small molecular polypeptide can promote the apoptosis of the intestinal epithelial cells and inhibit the proliferation of the intestinal epithelial cells in an in vitro cell experiment. The invention achieves the aim of blocking the inflammation-cancer conversion by interfering or blocking the biological function of the FKBP11 section of polypeptide, and provides a new drug design and a new therapeutic target for relieving enteritis related tumors. |
| priorityDate | 2016-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.