| abstract |
The present invention relates to a diphenylaminopyrimidine and triazine compound as shown in formula I, or a pharmaceutically acceptable salt, stereoisomer, hydrate or solvate thereof: Wherein: A is C or N; X, Y are independently selected from hydrogen, halogen, cyano, trifluoromethyl, alkoxy, alkyl, aromatic ring, alkenyl, alkynyl, nitro; or, X and Y together with the atoms to which they are attached form a benzene ring or an aromatic heterocycle; R 1 is R 2 is CD 3 or CD 2 CD 3 ; R 3 is selected from R 4 is selected from hydrogen, methyl, trifluoromethyl, cyano or halogen; R 5 is selected from hydrogen, alkyl, substituted and unsubstituted phenyl, allyl or propargyl; R 6 and R 7 are independently is selected from hydrogen, alkyl, substituted and unsubstituted phenyl, allyl, propargyl ; or, R and R together with the nitrogen atom to which they are attached form a substituted or unsubstituted heterocycloalkyl. The dianiline pyrimidine and triazine compounds of the invention have better pharmacodynamics and pharmacokinetic properties and ALK kinase inhibitory activity. |