http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106220545-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_582e9f70fb5113a2640c5de0193bd3c0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 |
| filingDate | 2016-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23e60b82d6d0f16c86fa27f89a3a25d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47dd9249b2f5be7ecaf7cec47f5a2e36 |
| publicationDate | 2016-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106220545-A |
| titleOfInvention | A kind of preparation method of ACEI medicine cyclohexyl impurity |
| abstract | The invention discloses the preparation method of a kind of ACEI medicine cyclohexyl impurity, comprise the following steps: former for ACEI medicine is dissolved in alcohol by (1), then glacial acetic acid and catalyst are added, after nitrogen replaces 3 times, it is passed through hydrogen, controlling Hydrogen Vapor Pressure is 10 50psi, and reaction temperature is 20 50 DEG C, and the response time is 6 48h；(2) by step (1) gained reacting liquid filtering, filtrate reduced in volume, thickening temperature is less than 35 DEG C, and then by isolated and purified for concentrate HPLC, material after purification continues concentrate drying and obtains ACEI medicine cyclohexyl impurity.This preparation process low cost, simple to operate, can be that the quality control of ACEI medicine provides reference substance qualified, cheap, that be easy to get. |
| priorityDate | 2016-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.