http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106191126-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-44 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106191126-B |
| titleOfInvention | Multifunctional alleles |
| abstract | Nucleic acid constructs and methods are provided for effecting modifications to a genome, wherein the modifications comprise null alleles, conditional alleles, and null alleles comprising COINs. Multifunctional alleles (MFAs) are provided, as well as methods for making the same, that provide the ability to introduce an allele in a single target, which can be used to generate null alleles, conditional alleles, or alleles that are null alleles and further include COINs. The MFA comprises a pair of cognate recombinase recognition sites, an initiation sequence and/or a drug selection cassette, and a nucleotide sequence of interest, and a COIN, wherein upon action of the recombinase, a conditional allele with a COIN is formed. In a further embodiment, the action of the second recombinase forms an allele that contains only the COIN in sense orientation. In a further embodiment, an allele containing only the promoter sequence in sense orientation is formed by the action of a third recombinase. |
| priorityDate | 2009-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 830.