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filingDate 2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106188577-A
titleOfInvention A hemicellulose-based light-responsive nanohydrogel and its preparation method and application
abstract The invention belongs to the technical field of gel materials, and discloses a hemicellulose-based light-responsive nano hydrogel, a preparation method and application thereof. The preparation method is as follows: react 1,6-dibromohexane and 4-hydroxyazobenzene to obtain 4-ω-bromohexyloxyazobenzene; then react it with hemicellulose to obtain side chain The azobenzene-containing amphiphilic hemicellulose derivative is dissolved in anhydrous DMSO and then transferred to a dialysis bag and dialyzed with distilled water for at least 24 hours to obtain the hemicellulose-based photoresponsive nano hydrogel. In the present invention, azobenzene is grafted into the hemicellulose molecular chain by graft copolymerization method, and then the hemicellulose-based light-responsive nano hydrogel is further prepared by using its hydrophobic association, which has higher light response efficiency, It has good biocompatibility and can better adapt to the environment of the human body. It has a good application prospect in the targeted slow-release treatment of local lesions of the human body after loading drugs.
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