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publicationDate 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-106187926-A
titleOfInvention Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof in the treatment of hyperuricemia and gout
abstract The invention relates to the medicine field of hyperuricemia and gout. Specifically, the present invention relates to a class of carboxylic acid uric acid transporter 1 (URAT1) inhibitors containing a diarylmethane structure, a preparation method thereof, a pharmaceutical composition containing them and their use in the preparation and treatment of hyperuricemia and Use in gout. Wherein, R 1 is selected from H, C 1 -C 10 alkyl, C 3 -C 10 cycloalkyl, F, Cl, Br, I, CN, NO 2 , SR 4 or OR 4 ; R 2 is selected from H, F, Cl, Br or I; R 3 is selected from H or C 1 -C 4 alkyl; X is selected from S or CH 2 ; wherein R 4 is selected from C 1 -C 10 alkyl.
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