abstract |
The invention relates to the medicine field of hyperuricemia and gout. Specifically, the present invention relates to a class of carboxylic acid uric acid transporter 1 (URAT1) inhibitors containing a diarylmethane structure, a preparation method thereof, a pharmaceutical composition containing them and their use in the preparation and treatment of hyperuricemia and Use in gout. Wherein, R 1 is selected from H, C 1 -C 10 alkyl, C 3 -C 10 cycloalkyl, F, Cl, Br, I, CN, NO 2 , SR 4 or OR 4 ; R 2 is selected from H, F, Cl, Br or I; R 3 is selected from H or C 1 -C 4 alkyl; X is selected from S or CH 2 ; wherein R 4 is selected from C 1 -C 10 alkyl. |