http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106187887-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1c821ac285a9501bb50a8622c695ebc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-56 |
| filingDate | 2016-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60734f64f6f8cbc5434d9df947dbdb60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_094accbb96653235e802e4bfb3350f97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bb5779a98216e8a59dcb91ad90bd1cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d62373841f1aaef7b543c412be7a88f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ac2a603c49de760213e7f06419b122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef010b39a3071c23a6d2fc65acb9b343 |
| publicationDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106187887-A |
| titleOfInvention | The preparation method of 4 hydroxyquinoline 3 formic acid |
| abstract | The present invention relates to organic synthesis and the preparing technical field of crude drug intermediate, it is specifically related to the cystic fibrosis therapies new drug preparation method according to key intermediate 4 hydroxyquinoline 3 formic acid cutting down Kato, comprise the steps: (1) condensation reaction: with o-Carboxynitrobenzene, potassium ethyl malonate salt, N, N carbonyl dimidazoles is raw material, and reaction prepares 3 (2 nitrobenzophenone) 3 oxopropanoate；(2) reduction reaction: 3 (2 nitrobenzophenone) 3 oxopropanoate prepare 3 (2 aminophenyl) 3 oxopropanoate through catalytic hydrogen reduction；(3) ring-closure reaction: 3 (2 aminophenyl) 3 oxopropanoate and N, N Dimethylformamide dimethyl acetal, obtains 4 hydroxyquinoline 3 Ethyl formates through nucleophilic addition, ring-closure reaction；(4) hydrolysis: 4 hydroxyquinoline 3 Ethyl formates, through hydrolysis, obtain 4 hydroxyquinoline 3 formic acid.This synthetic route raw material is easy to get, reaction condition gentle, post processing is simple and convenient, is suitable for amplifying preparation, and yield is high. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113402459-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108499614-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108499614-B |
| priorityDate | 2016-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.