http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106187806-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90adb7bd5ccba3a6a260936168da89ad |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate | 2016-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae43660ea06e521dd6a01b542d69e0e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09a5e94c0a3bb66122af9927ddf7998a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54fc7ee6319ef445ea289e365c14ee14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe6e73552b2ecf28d0687f08749161c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5790ea8592e78781387568bc9277143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb1e226a9fed419298b9d4cd64edf388 |
| publicationDate | 2016-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106187806-A |
| titleOfInvention | A kind of crocetin derivative GX‑F, its preparation method, and its application in the prevention or treatment of cardiovascular and cerebrovascular diseases |
| abstract | The present invention relates to a kind of crocetin amide GX-F and preparation method thereof, and its preparation method comprises the following steps: a, take crocetin, EDCl (1-ethyl-(3-dimethylaminopropyl) Carbodiimide salt), HOBt (1-hydroxybenzotriazole) in the reaction flask; under ice bath conditions, add Et 3 N, CH 2 Cl 2 , then add organic amine compounds, and react at 0°C 2‑8 hours, overnight at room temperature; b. After the reaction is complete, stop the reaction; filter the reaction solution, remove the solvent, add EA to dissolve, and wash; after removing the solvent, the crude product is obtained; c. Separate the crude product with a silica gel column and elute , to obtain the product; the crocinamide derivatives GX-F involved in the present invention can be prepared into oral preparations such as tablets, sustained-release tablets, granules, and suspensions for preventing or treating cardiovascular and cerebrovascular diseases, and its clinical application more extensive. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108403677-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108403677-B |
| priorityDate | 2016-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.